Research

My passion and curiosity for physics and medicine guided me to the world of medical imaging, where I've focused on advancing Positron Emission Tomography (PET) to address shortcomings in current technologies and improve patient outcomes. My research spans the development of novel PET imaging systems, solid-state imaging sensors, and advanced reconstruction algorithms for clinical applications.

I am particularily proud of my role in the development and commercialization of the Radialis PET Imager, a breakthrough organ-targeted PET device that delivers best-in-class performance and is used for the detection and management of diseases ranging from breast cancer to Alzheimer's.

Beyond this, I have extensive experience in regulatory compliance (FDA, Health Canada) and in building and maintaining medical device quality management systems (ISO 13485:2016, MDSAP), ensuring that innovation exceeds the highest standards of safety and effectiveness. If you're interested in learning more about my work, please explore my publications below or reach out to me directly.

Image quality evaluation for a clinical organ-targeted PET camera

The following article outlines a subset of my academic reasearch and was published in Frontiers in Oncology in March of 2024. Click here for the full text Baldassi B, Poladyan H, Shahi A, Maa-Hacquoil H, Rapley M, Komarov B, Stiles J, Freitas V, Waterston M, Aseyev O, Reznik A, Bubon O. Image quality evaluation for a clinical organ-targeted PET camera. Front Oncol. 2024 Mar 25;14:1268991. doi: 10.3389/fonc.2024.1268991. PMID: 38590664; PMCID: PMC10999605....

Multi-angle acquisition and 3D composite reconstruction for organ-targeted PET using planar detectors

The following case report outlines a subset of my academic reasearch and was published in Medical Physics in December of 2024. Click here for the full text Shahi A, Poladyan H, Anashkin E, Komarov B, Baldassi B, Rapley M, Babich A, Bubon O, Reznik A. Multi-angle acquisition and 3D composite reconstruction for organ-targeted PET using planar detectors. Med Phys. 2024 Dec 27. doi: 10.1002/mp.17606. Epub ahead of print. PMID: 39729623....

Breast Cancer Detection Using a Low-Dose Positron Emission Digital Mammography System

The following article outlines a subset of my academic reasearch and was published in Radiology: Imaging Cancer in February of 2024. Click here for the full text Freitas V, Li X, Scaranelo A, Au F, Kulkarni S, Ghai S, Taeb S, Bubon O, Baldassi B, Komarov B, Parker S, Macsemchuk CA, Waterston M, Olsen KO, Reznik A. Breast Cancer Detection Using a Low-Dose Positron Emission Digital Mammography System. Radiol Imaging Cancer....

Case report: Possible role of low-dose PEM for avoiding unneeded procedures associated with false-positive or equivocal breast MRI results

The following case report outlines a subset of my academic reasearch and was published in Frontiers in Oncology in July of 2024. Click here for the full text Rapley M, Freitas V, Weinberg IN, Baldassi B, Poladyan H, Waterston M, Ghai S, Taeb S, Bubon O, Mulligan AM, Reznik A. Case report: Possible role of low-dose PEM for avoiding unneeded procedures associated with false-positive or equivocal breast MRI results. Front Oncol....

Evaluation of a High-Sensitivity Organ-Targeted PET Camera

The following article outlines a subset of my academic reasearch and was published in Sensors in June of 2022. Click here for the full text Stiles J, Baldassi B, Bubon O, Poladyan H, Freitas V, Scaranelo A, Mulligan AM, Waterston M, Reznik A. Evaluation of a High-Sensitivity Organ-Targeted PET Camera. Sensors (Basel). 2022 Jun 21;22(13):4678. doi: 10.3390/s22134678. PMID: 35808181; PMCID: PMC9269056. Astract The aim of this study is to evaluate the performance of the Radialis organ-targeted positron emission tomography (PET) Camera with standardized tests and through assessment of clinical-imaging results....

Characterization of cadmium zinc telluride (CZT) as a material for solid-state detectors in advanced Computed Tomography (CT) applications.

The following page outlines a subset of my academic reasearch performed during the summer of 2016 and published in the Journal of Materials Science: Materials in Electronics in 2018 Abstract Although cadmium zinc telluride (CZT) is the most widely used room-temperature photoconductor for low ﬂux radiation sensing, utilization of this promising material in high ﬂux applications, like computed tomography is challenging, due to possible dynamic polarization. Indeed, trapping of the X-ray-generated charge may cause space charge build-up and electric ﬁeld distortion....

Development of a Novel Drone-Mounted Radioactive Contamination Localization System

This research project was conducted at McMaster University under the supervision of Dr. Troy Farncombe. Abstract The precise localization and quantification of radioactivity in an emergency-response scenario is critical for public safety and informed remediation efforts. The proposed drone-based radioactive contamination localization system is designed with the intention of addressing the shortcomings of conventional radiation surveying techniques. A unique 3x3 detector geometry implementing high-performing scintillator crystals and solid-state silicon-based detectors is proposed which allows for reconstruction of the spatial distribution of radioactivity....